When does chloride shift occur

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Trial results on Chloride shift. Clinical Trials on Chloride shift at Google. FDA on Chloride shift. CDC on Chloride shift. Books on Chloride shift. Fairbanks, G. Steck, and D. Wieth, J. Munksgaard, Copenhagen : Brix, Ole, et al. B, Comparative biochemistry The erythrocyte chloride shift Hamburger effect. All SAQs related to this topic. All vivas related to this topic. In summary: The chloride shift or "Hamburger effect" describes the movement of chloride into RBCs which occurs when the buffer effects of deoxygenated haemoglobin increase the intracellular bicarbonate concentration, and the bicarbonate is exported from the RBC in exchange for chloride.

The mechanism of the chloride shift: Chloride moves into erythrocytes, and bicarbonate moves out, in venous blood. The traditional explanation for the chloride shift emphasizes the causative roles of the rise in Pco 2 and the exclusive presence of carbonic anhydrase within the red blood cell.

The purpose of this article is, first, to reexamine two aspects of the chloride shift that we feel are traditionally underemphasized. They are the role of hemoglobin in causing the chloride shift and the affect of the chloride shift on the acid-base status of the blood.

Second, we wish to reconcile more recent work with the traditional understanding of the chloride shift.